DNA damage during S-phase mediates the proliferation-quiescence decision in the subsequent G1 via p21 expression

Following DNA damage caused by exogenous sources, such as ionizing radiation, the tumour suppressor p53 mediates cell cycle arrest via expression of the CDK inhibitor, p21. However, the role of p21 in maintaining genomic stability in the absence of exogenous DNA-damaging agents is unclear. Here, usi...

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Argitaratua izan da:Nat Commun
Egile Nagusiak: Barr, Alexis R., Cooper, Samuel, Heldt, Frank S., Butera, Francesca, Stoy, Henriette, Mansfeld, Jörg, Novák, Béla, Bakal, Chris
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group 2017
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5364389/
https://ncbi.nlm.nih.gov/pubmed/28317845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14728
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