Restoring the oncosuppressor activity of microRNA-34a in glioblastoma using a polyglycerol-based polyplex

Glioblastoma multiforme (GBM) is the most common and aggressive primary neoplasm of the brain. Poor prognosis is mainly attributed to tumor heterogeneity, invasiveness, and drug resistance. microRNA-based therapeutics represent a promising approach due to their ability to inhibit multiple targets. I...

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Veröffentlicht in:Nanomedicine
Hauptverfasser: Ofek, Paula, Calderón, Marcelo, Mehrabadi, Fatemeh Sheikhi, Krivitsky, Adva, Ferber, Shiran, Tiram, Galia, Yerushalmi, Noga, Kredo-Russo, Sharon, Grossman, Rachel, Ram, Zvi, Haag, Rainer, Satchi-Fainaro, Ronit
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2016
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5364374/
https://ncbi.nlm.nih.gov/pubmed/27262933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nano.2016.05.016
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