Co-targeting the tumor endothelium and P-selectin-expressing glioblastoma cells leads to a remarkable therapeutic outcome

Glioblastoma is a highly aggressive brain tumor. Current standard-of-care results in a marginal therapeutic outcome, partly due to acquirement of resistance and insufficient blood-brain barrier (BBB) penetration of chemotherapeutics. To circumvent these limitations, we conjugated the chemotherapy pa...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Ferber, Shiran, Tiram, Galia, Sousa-Herves, Ana, Eldar-Boock, Anat, Krivitsky, Adva, Scomparin, Anna, Yeini, Eilam, Ofek, Paula, Ben-Shushan, Dikla, Vossen, Laura Isabel, Licha, Kai, Grossman, Rachel, Ram, Zvi, Henkin, Jack, Ruppin, Eytan, Auslander, Noam, Haag, Rainer, Calderón, Marcelo, Satchi-Fainaro, Ronit
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2017
Assuntos:
Cancer Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5644959/
https://ncbi.nlm.nih.gov/pubmed/28976305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.25281
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