Amphiphilic nanocarrier-induced modulation of PLK1 and miR-34a leads to improved therapeutic response in pancreatic cancer

The heterogeneity of pancreatic ductal adenocarcinoma (PDAC) suggests that successful treatment might rely on simultaneous targeting of multiple genes, which can be achieved by RNA interference-based therapeutic strategies. Here we show a potent combination of microRNA and siRNA delivered by an effi...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Gibori, Hadas, Eliyahu, Shay, Krivitsky, Adva, Ben-Shushan, Dikla, Epshtein, Yana, Tiram, Galia, Blau, Rachel, Ofek, Paula, Lee, Joo Sang, Ruppin, Eytan, Landsman, Limor, Barshack, Iris, Golan, Talia, Merquiol, Emmanuelle, Blum, Galia, Satchi-Fainaro, Ronit
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5750234/
https://ncbi.nlm.nih.gov/pubmed/29295989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-02283-9
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