The Severity of Plasmodium falciparum Infection Is Associated with Transcript Levels of var Genes Encoding Endothelial Protein C Receptor-Binding P. falciparum Erythrocyte Membrane Protein 1

By attaching infected erythrocytes to the vascular lining, Plasmodium falciparum parasites leave blood circulation and avoid splenic clearance. This sequestration is central to pathogenesis. Severe malaria is associated with parasites expressing an antigenically distinct P. falciparum erythrocyte me...

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Udgivet i:Infect Immun
Main Authors: Mkumbaye, Sixbert I., Wang, Christian W., Lyimo, Eric, Jespersen, Jakob S., Manjurano, Alphaxard, Mosha, Jacklin, Kavishe, Reginald A., Mwakalinga, Steven B., Minja, Daniel T. R., Lusingu, John P., Theander, Thor G., Lavstsen, Thomas
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2017
Fag:
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5364309/
https://ncbi.nlm.nih.gov/pubmed/28138022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00841-16
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