Mucosal Antibodies to the C Terminus of Toxin A Prevent Colonization of Clostridium difficile

Mucosal immunity is considered important for protection against Clostridium difficile infection (CDI). We show that in hamsters immunized with Bacillus subtilis spores expressing a carboxy-terminal segment (TcdA(26–39)) of C. difficile toxin A, no colonization occurs in protected animals when challe...

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Udgivet i:Infect Immun
Main Authors: Hong, Huynh A., Hitri, Krisztina, Hosseini, Siamand, Kotowicz, Natalia, Bryan, Donna, Mawas, Fatme, Wilkinson, Anthony J., van Broekhoven, Annie, Kearsey, Jonathan, Cutting, Simon M.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2017
Fag:
Microbial Immunity and Vaccines
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5364299/
https://ncbi.nlm.nih.gov/pubmed/28167669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01060-16
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