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Cellular Uptake of Clostridium botulinum C2 Toxin Requires Acid Sphingomyelinase Activity
Clostridium botulinum C2 toxin consists of an enzyme component (C2I) and a binding component (C2II). Activated C2II (C2IIa) binds to a cell receptor, giving rise to lipid raft-dependent oligomerization, and it then assembles with C2I. The whole toxin complex is then endocytosed into the cytosol, res...
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| Publicado no: | Infect Immun |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5364297/ https://ncbi.nlm.nih.gov/pubmed/28138018 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00966-16 |
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