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Acid Sphingomyelinase Promotes Cellular Internalization of Clostridium perfringens Iota-Toxin
Clostridium perfringens iota-toxin is a binary actin-ADP-ribosylating toxin composed of the enzymatic component Ia and receptor binding component Ib. Ib binds to a cell surface receptor, forms Ib oligomer in lipid rafts, and associates with Ia. The Ia-Ib complex then internalizes by endocytosis. Her...
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| Publicado no: | Toxins (Basel) |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
MDPI
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5983265/ https://ncbi.nlm.nih.gov/pubmed/29783772 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/toxins10050209 |
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