Overlapping and Divergent Actions of Structurally Distinct Histone Deacetylase Inhibitors in Cardiac Fibroblasts

Inhibitors of zinc-dependent histone deacetylases (HDACs) profoundly affect cellular function by altering gene expression via changes in nucleosomal histone tail acetylation. Historically, investigators have employed pan-HDAC inhibitors, such as the hydroxamate trichostatin A (TSA), which simultaneo...

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Detalhes bibliográficos
Publicado no:J Pharmacol Exp Ther
Main Authors: Schuetze, Katherine B., Stratton, Matthew S., Blakeslee, Weston W., Wempe, Michael F., Wagner, Florence F., Holson, Edward B., Kuo, Yin-Ming, Andrews, Andrew J., Gilbert, Tonya M., Hooker, Jacob M., McKinsey, Timothy A.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2017
Assuntos:
Cellular and Molecular
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5363768/
https://ncbi.nlm.nih.gov/pubmed/28174211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.116.237701
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