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Structural and Preclinical Studies of Computationally Designed Non-Nucleoside Reverse Transcriptase Inhibitors for Treating HIV infection

The clinical benefits of HIV-1 non-nucleoside reverse transcriptase (RT) inhibitors (NNRTIs) are hindered by their unsatisfactory pharmacokinetic (PK) properties along with the rapid development of drug-resistant variants. However, the clinical efficacy of these inhibitors can be improved by develop...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Mol Pharmacol
Main Authors: Kudalkar, Shalley N., Beloor, Jagadish, Chan, Albert H., Lee, Won-Gil, Jorgensen, William L., Kumar, Priti, Anderson, Karen S.
פורמט: Artigo
שפה:Inglês
יצא לאור: The American Society for Pharmacology and Experimental Therapeutics 2017
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC5363707/
https://ncbi.nlm.nih.gov/pubmed/28167742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.116.107755
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