Quantitative proteomics reveals molecular mechanism of gamabufotalin and its potential inhibition on Hsp90 in lung cancer

Gamabufotalin (CS-6) is a major bufadienolide of Chansu, which shows desirable metabolic stability and less adverse effect in cancer therapy. CS-6 treatment inhibited the proliferation of NSCLC in a nanomolar range. And CS-6 could induce G2/M cell cycle arrest and apoptosis in A549 cells. However, i...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Zhang, Liyuan, Yu, Zhenlong, Wang, Yan, Wang, Xiaobo, Zhang, Lianru, Wang, Chao, Yue, Qingxi, Wang, Xun, Deng, Sa, Huo, Xiaokui, Tian, Xiangge, Huang, Shanshan, Zhang, Baojing, Ma, Xiaochi
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5363529/
https://ncbi.nlm.nih.gov/pubmed/27384878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10388
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