RNA-Guided CRISPR-Cas9 System-Mediated Engineering of Acute Myeloid Leukemia Mutations

Current acute myeloid leukemia (AML) disease models face severe limitations because most of them induce un-physiological gene expressions that do not represent conditions in AML patients and/or depend on external promoters for regulation of gene expression/repression. Furthermore, many AML models ar...

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Publicat a:Mol Ther Nucleic Acids
Autors principals: Brabetz, Oliver, Alla, Vijay, Angenendt, Linus, Schliemann, Christoph, Berdel, Wolfgang E., Arteaga, Maria-Francisca, Mikesch, Jan-Henrik
Format: Artigo
Idioma:Inglês
Publicat: American Society of Gene & Cell Therapy 2017
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5363507/
https://ncbi.nlm.nih.gov/pubmed/28325290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2016.12.012
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