Scaffold-mediated CRISPR-Cas9 delivery system for acute myeloid leukemia therapy

Leukemia stem cells (LSCs) sustain the disease and contribute to relapse in acute myeloid leukemia (AML). Therapies that ablate LSCs may increase the chance of eliminating this cancer in patients. To this end, we used a bioreducible lipidoid-encapsulated Cas9/single guide RNA (sgRNA) ribonucleoprote...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Ho, Tzu-Chieh, Kim, Hye Sung, Chen, Yumei, Li, Yamin, LaMere, Mark W., Chen, Caroline, Wang, Hui, Gong, Jing, Palumbo, Cal D., Ashton, John M., Kim, HaeWon, Xu, Qiaobing, Becker, Michael W., Leong, Kam W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2021
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8133753/
https://ncbi.nlm.nih.gov/pubmed/34138728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abg3217
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