Type I Interferons Impede Short Hairpin RNA-Mediated RNAi via Inhibition of Dicer-Mediated Processing to Small Interfering RNA

RNAi by short hairpin RNA (shRNA) is a powerful tool not only for studying gene functions in various organisms, including mammals, but also for the treatment of severe disorders. However, shRNA-expressing vectors can induce type I interferon (IFN) expression by activation of innate immune responses,...

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Pubblicato in:Mol Ther Nucleic Acids
Autori principali: Machitani, Mitsuhiro, Sakurai, Fuminori, Wakabayashi, Keisaku, Takayama, Kosuke, Tachibana, Masashi, Mizuguchi, Hiroyuki
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Gene & Cell Therapy 2017
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5363498/
https://ncbi.nlm.nih.gov/pubmed/28325284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2016.12.007
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