Aptamer-Drug Conjugates of Active Metabolites of Nucleoside Analogs and Cytotoxic Agents Inhibit Pancreatic Tumor Cell Growth

Aptamer-drug conjugates (ApDCs) have the potential to improve the therapeutic index of traditional chemotherapeutic agents due to their ability to deliver cytotoxic drugs specifically to cancer cells while sparing normal cells. This study reports on the conjugation of cytotoxic drugs to an aptamer p...

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Detalles Bibliográficos
Publicado en:Mol Ther Nucleic Acids
Autores principales: Yoon, Sorah, Huang, Kai-Wen, Reebye, Vikash, Spalding, Duncan, Przytycka, Teresa M., Wang, Yijie, Swiderski, Piotr, Li, Lin, Armstrong, Brian, Reccia, Isabella, Zacharoulis, Dimitris, Dimas, Konstantinos, Kusano, Tomokazu, Shively, John, Habib, Nagy, Rossi, John J.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Gene & Cell Therapy 2017
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5363417/
https://ncbi.nlm.nih.gov/pubmed/28325302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2016.11.008
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