Genome-wide Specificity of Highly Efficient TALENs and CRISPR/Cas9 for T Cell Receptor Modification

In T cells with transgenic high-avidity T cell receptors (TCRs), endogenous and transferred TCR chains compete for surface expression and may pair inappropriately, potentially causing autoimmunity. To knock out endogenous TCR expression, we assembled 12 transcription activator-like effector nuclease...

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Bibliografiset tiedot
Julkaisussa:Mol Ther Methods Clin Dev
Päätekijät: Knipping, Friederike, Osborn, Mark J., Petri, Karl, Tolar, Jakub, Glimm, Hanno, von Kalle, Christof, Schmidt, Manfred, Gabriel, Richard
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society of Gene & Cell Therapy 2017
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Original Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5363317/
https://ncbi.nlm.nih.gov/pubmed/28345006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2017.01.005
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