Genome-wide Specificity of Highly Efficient TALENs and CRISPR/Cas9 for T Cell Receptor Modification

In T cells with transgenic high-avidity T cell receptors (TCRs), endogenous and transferred TCR chains compete for surface expression and may pair inappropriately, potentially causing autoimmunity. To knock out endogenous TCR expression, we assembled 12 transcription activator-like effector nuclease...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Mol Ther Methods Clin Dev
Main Authors: Knipping, Friederike, Osborn, Mark J., Petri, Karl, Tolar, Jakub, Glimm, Hanno, von Kalle, Christof, Schmidt, Manfred, Gabriel, Richard
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2017
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5363317/
https://ncbi.nlm.nih.gov/pubmed/28345006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2017.01.005
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados