Homology-Directed Recombination for Enhanced Engineering of Chimeric Antigen Receptor T Cells

Gene editing by homology-directed recombination (HDR) can be used to couple delivery of a therapeutic gene cassette with targeted genomic modifications to generate engineered human T cells with clinically useful profiles. Here, we explore the functionality of therapeutic cassettes delivered by these...

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Detalhes bibliográficos
Publicado no:Mol Ther Methods Clin Dev
Main Authors: Hale, Malika, Lee, Baeckseung, Honaker, Yuchi, Leung, Wai-Hang, Grier, Alexandra E., Jacobs, Holly M., Sommer, Karen, Sahni, Jaya, Jackson, Shaun W., Scharenberg, Andrew M., Astrakhan, Alexander, Rawlings, David J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2017
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5363294/
https://ncbi.nlm.nih.gov/pubmed/28345004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2016.12.008
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