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Homology-Directed Recombination for Enhanced Engineering of Chimeric Antigen Receptor T Cells
Gene editing by homology-directed recombination (HDR) can be used to couple delivery of a therapeutic gene cassette with targeted genomic modifications to generate engineered human T cells with clinically useful profiles. Here, we explore the functionality of therapeutic cassettes delivered by these...
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| Publié dans: | Mol Ther Methods Clin Dev |
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| Auteurs principaux: | , , , , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society of Gene & Cell Therapy
2017
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5363294/ https://ncbi.nlm.nih.gov/pubmed/28345004 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2016.12.008 |
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