Rapid Asymmetric Synthesis of Disubstituted Allenes by Coupling of Flow‐Generated Diazo Compounds and Propargylated Amines

We report herein the asymmetric coupling of flow‐generated unstabilized diazo compounds and propargylated amine derivatives, using a new pyridinebis(imidazoline) ligand, a copper catalyst and base. The reaction proceeds rapidly, generating chiral allenes in 10–20 minutes with high enantioselectivity...

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Detaylı Bibliyografya
Yayımlandı:Angew Chem Int Ed Engl
Asıl Yazarlar: Poh, Jian‐Siang, Makai, Szabolcs, von Keutz, Timo, Tran, Duc N., Battilocchio, Claudio, Pasau, Patrick, Ley, Steven V.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: John Wiley and Sons Inc. 2017
Konular:
Communications
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5363227/
https://ncbi.nlm.nih.gov/pubmed/28075518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201611067
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