Laddar...

Rapid Asymmetric Synthesis of Disubstituted Allenes by Coupling of Flow‐Generated Diazo Compounds and Propargylated Amines

We report herein the asymmetric coupling of flow‐generated unstabilized diazo compounds and propargylated amine derivatives, using a new pyridinebis(imidazoline) ligand, a copper catalyst and base. The reaction proceeds rapidly, generating chiral allenes in 10–20 minutes with high enantioselectivity...

Full beskrivning

Sparad:
Bibliografiska uppgifter
I publikationen:Angew Chem Int Ed Engl
Huvudupphovsmän: Poh, Jian‐Siang, Makai, Szabolcs, von Keutz, Timo, Tran, Duc N., Battilocchio, Claudio, Pasau, Patrick, Ley, Steven V.
Materialtyp: Artigo
Språk:Inglês
Publicerad: John Wiley and Sons Inc. 2017
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5363227/
https://ncbi.nlm.nih.gov/pubmed/28075518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201611067
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!