Rapid Asymmetric Synthesis of Disubstituted Allenes by Coupling of Flow‐Generated Diazo Compounds and Propargylated Amines

We report herein the asymmetric coupling of flow‐generated unstabilized diazo compounds and propargylated amine derivatives, using a new pyridinebis(imidazoline) ligand, a copper catalyst and base. The reaction proceeds rapidly, generating chiral allenes in 10–20 minutes with high enantioselectivity...

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發表在:Angew Chem Int Ed Engl
Main Authors: Poh, Jian‐Siang, Makai, Szabolcs, von Keutz, Timo, Tran, Duc N., Battilocchio, Claudio, Pasau, Patrick, Ley, Steven V.
格式: Artigo
語言:Inglês
出版: John Wiley and Sons Inc. 2017
主題:
Communications
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5363227/
https://ncbi.nlm.nih.gov/pubmed/28075518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201611067
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