Motor-Coordinative and Cognitive Dysfunction Caused by Mutant TDP-43 Could Be Reversed by Inhibiting Its Mitochondrial Localization

Dominant missense mutations in TAR DNA-binding protein 43 (TDP-43) cause amyotrophic lateral sclerosis (ALS), and the cytoplasmic accumulation of TDP-43 represents a pathological hallmark in ALS and frontotemporal lobar degeneration (FTD). Behavioral investigation of the transgenic mouse model expre...

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Pubblicato in:Mol Ther
Autori principali: Wang, Wenzhang, Arakawa, Hiroyuki, Wang, Luwen, Okolo, Ogoegbunam, Siedlak, Sandra L., Jiang, Yinfei, Gao, Ju, Xie, Fei, Petersen, Robert B., Wang, Xinglong
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Gene & Cell Therapy 2017
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5363201/
https://ncbi.nlm.nih.gov/pubmed/28129109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2016.10.013
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