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TDP-43 proteinopathy and mitochondrial abnormalities in neurodegeneration

Genetic mutations in TAR DNA-binding protein 43 (TDP-43) cause amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Importantly, TDP-43 proteinopathy, characterized by aberrant phosphorylation, ubiquitination, cleavage or nuclear depletion of TDP-43 in neurons and glial cells, is a...

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Bibliografske podrobnosti
izdano v:Mol Cell Neurosci
Main Authors: Gao, Ju, Wang, Luwen, Yan, Tingxiang, Perry, George, Wang, Xinglong
Format: Artigo
Jezik:Inglês
Izdano: 2019
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6874890/
https://ncbi.nlm.nih.gov/pubmed/31445085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mcn.2019.103396
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