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TDP-43 proteinopathy and mitochondrial abnormalities in neurodegeneration

Genetic mutations in TAR DNA-binding protein 43 (TDP-43) cause amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Importantly, TDP-43 proteinopathy, characterized by aberrant phosphorylation, ubiquitination, cleavage or nuclear depletion of TDP-43 in neurons and glial cells, is a...

詳細記述

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書誌詳細
出版年:Mol Cell Neurosci
主要な著者: Gao, Ju, Wang, Luwen, Yan, Tingxiang, Perry, George, Wang, Xinglong
フォーマット: Artigo
言語:Inglês
出版事項: 2019
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6874890/
https://ncbi.nlm.nih.gov/pubmed/31445085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mcn.2019.103396
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