Janus-faced Acrolein prevents allergy but accelerates tumor growth by promoting immunoregulatory Foxp3+ cells: Mouse model for passive respiratory exposure

Acrolein, a highly reactive unsaturated aldehyde, is generated in large amounts during smoking and is best known for its genotoxic capacity. Here, we aimed to assess whether acrolein at concentrations relevant for smokers may also exert immunomodulatory effects that could be relevant in allergy or c...

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Détails bibliographiques
Publié dans:Sci Rep
Auteurs principaux: Roth-Walter, Franziska, Bergmayr, Cornelia, Meitz, Sarah, Buchleitner, Stefan, Stremnitzer, Caroline, Fazekas, Judit, Moskovskich, Anna, Müller, Mario A., Roth, Georg A., Manzano-Szalai, Krisztina, Dvorak, Zdenek, Neunkirchner, Alina, Jensen-Jarolim, Erika
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2017
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5362909/
https://ncbi.nlm.nih.gov/pubmed/28332605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep45067
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