Epigenetic silencing of XAF1 in high-grade gliomas is associated with IDH1 status and improved clinical outcome

XAF1 (X-linked inhibitor of apoptosis (XIAP)-associated factor 1) is a tumor suppressor that counteracts the anti-apoptotic effects of XIAP and can sensitize cells to cell death triggering events. XAF1 knockdown abrogated the temozolomide (TMZ)-induced G2-arrest and prevented TMZ-induced apoptosis i...

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Udgivet i:Oncotarget
Main Authors: Reich, Thomas R., Switzeny, Olivier J., Renovanz, Mirjam, Sommer, Clemens, Kaina, Bernd, Christmann, Markus, Tomicic, Maja T.
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2017
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5362468/
https://ncbi.nlm.nih.gov/pubmed/28122345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.14748
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