Integrin αVβ3 silencing sensitizes malignant glioma cells to temozolomide by suppression of homologous recombination repair

Integrins have been suggested as possible targets in anticancer therapy. Here we show that knockdown of integrins αVβ3, αVβ5, α3β1 and α4β1 and pharmacological inhibition using a cyclo-RGD integrin αVβ3/αVβ5 antagonist sensitized multiple high-grade glioma cell lines to temozolomide (TMZ)-induced cy...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Christmann, Markus, Diesler, Kathrin, Majhen, Dragomira, Steigerwald, Christian, Berte, Nancy, Freund, Halima, Stojanović, Nikolina, Kaina, Bernd, Osmak, Maja, Ambriović-Ristov, Andreja, Tomicic, Maja T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2016
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5438606/
https://ncbi.nlm.nih.gov/pubmed/27487141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10897
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