MGMT promoter methylation determined by HRM in comparison to MSP and pyrosequencing for predicting high-grade glioma response

BACKGROUND: The DNA repair protein O(6)-methylguanine-DNA methyltransferase (MGMT) causes resistance of cancer cells to alkylating agents and, therefore, is a well-established predictive marker for high-grade gliomas that are routinely treated with alkylating drugs. Since MGMT is highly epigenetical...

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Publicat a:Clin Epigenetics
Autors principals: Switzeny, Olivier J., Christmann, Markus, Renovanz, Mirjam, Giese, Alf, Sommer, Clemens, Kaina, Bernd
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2016
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4858829/
https://ncbi.nlm.nih.gov/pubmed/27158275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13148-016-0204-7
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