Distinct patterns of infiltrating CD8+ T cells in HPV+ and CD68 macrophages in HPV- oropharyngeal squamous cell carcinomas are associated with better clinical outcome but PD-L1 expression is not prognostic

Immunotherapies are beginning to revolutionise treatment paradigms in oncology with monoclonal antibodies (mAb) targeting T-cell co-inhibitory (e.g. PD-1/PD-L1) and co-stimulatory pathways (e.g. CTLA-4/CD28) demonstrating clinical utility. Some clinical studies demonstrate that responsiveness to PD-...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Oguejiofor, Kenneth, Galletta-Williams, Henry, Dovedi, Simon J., Roberts, Darren L., Stern, Peter L., West, Catharine M.L.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5362415/
https://ncbi.nlm.nih.gov/pubmed/28122336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.14796
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