Pravastatin activates activator protein 2 alpha to augment the angiotensin II-induced abdominal aortic aneurysms

We have previously reported that activation of AMP-activated kinase alpha 2 (AMPKa2) by nicotine or angiotensin II (AngII) instigates formation of abdominal aortic aneurysms (AAA) in Apoe−/− mice. Statins, used to treat hyperlipidemia widely, activate AMPK in vascular cells. We sought to examine the...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Ma, Hui, Liang, Wen-Jing, Shan, Mei-Rong, Wang, Xue-Qing, Zhou, Sheng-Nan, Chen, Yuan, Guo, Tao, Li, Peng, Yu, Hai-Ya, Liu, Chao, Yin, Ya-Ling, Wang, Yu-Lin, Dong, Bo, Pang, Xin-Yan, Wang, Shuang-Xi
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper: Pathology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5362406/
https://ncbi.nlm.nih.gov/pubmed/28179583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.15104
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