Melatonin attenuates angiotensin II-induced abdominal aortic aneurysm through the down-regulation of matrix metalloproteinases

Abdominal aortic aneurysm (AAA) affects more than 5% of the population in developed countries and the pharmacotherapies for AAA are limited. Here, we explored whether melatonin regulates the development of AAA. In smooth muscle cells, melatonin treatment decreases angiotensin II-induced matrix metal...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Kong, Jing, Zhang, Ya, Liu, Shanshan, Li, Hongxuan, Liu, Shangming, Wang, Jingjing, Qin, Xiaoteng, Jiang, Xiuxin, Yang, Jianmin, Zhang, Cheng, Zhang, Wencheng
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper: Pathology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5362405/
https://ncbi.nlm.nih.gov/pubmed/28179581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.15093
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