Melatonin attenuates angiotensin II-induced abdominal aortic aneurysm through the down-regulation of matrix metalloproteinases

Abdominal aortic aneurysm (AAA) affects more than 5% of the population in developed countries and the pharmacotherapies for AAA are limited. Here, we explored whether melatonin regulates the development of AAA. In smooth muscle cells, melatonin treatment decreases angiotensin II-induced matrix metal...

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Bibliographische Detailangaben
Veröffentlicht in:Oncotarget
Hauptverfasser: Kong, Jing, Zhang, Ya, Liu, Shanshan, Li, Hongxuan, Liu, Shangming, Wang, Jingjing, Qin, Xiaoteng, Jiang, Xiuxin, Yang, Jianmin, Zhang, Cheng, Zhang, Wencheng
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2017
Schlagworte:
Research Paper: Pathology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5362405/
https://ncbi.nlm.nih.gov/pubmed/28179581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.15093
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