Vascular endothelial overexpression of human CYP2J2 (Tie2-CYP2J2 Tr) modulates cardiac oxylipin profiles and enhances coronary reactive hyperemia in mice

Arachidonic acid is metabolized to epoxyeicosatrienoic acids (EETs) by cytochrome (CYP) P450 epoxygenases, and to ω-terminal hydroxyeicosatetraenoic acids (HETEs) by ω-hydroxylases. EETs and HETEs often have opposite biologic effects; EETs are vasodilatory and protect against ischemia/reperfusion in...

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Publicado en:PLoS One
Autores principales: Hanif, Ahmad, Edin, Matthew L., Zeldin, Darryl C., Morisseau, Christophe, Falck, John R., Nayeem, Mohammed A.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2017
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5362206/
https://ncbi.nlm.nih.gov/pubmed/28328948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0174137
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