Deletion of soluble epoxide hydrolase enhances coronary reactive hyperemia in isolated mouse heart: role of oxylipins and PPARγ

The relationship between soluble epoxide hydrolase (sEH) and coronary reactive hyperemia (CRH) response to a brief ischemic insult is not known. Epoxyeicosatrienoic acids (EETs) exert cardioprotective effects in ischemia/reperfusion injury. sEH converts EETs into dihydroxyeicosatrienoic-acids (DHETs...

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Veröffentlicht in:Am J Physiol Regul Integr Comp Physiol
Hauptverfasser: Hanif, Ahmad, Edin, Matthew L., Zeldin, Darryl C., Morisseau, Christophe, Nayeem, Mohammed A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Physiological Society 2016
Schlagworte:
Cardiovascular and Renal Integration
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5142160/
https://ncbi.nlm.nih.gov/pubmed/27488890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpregu.00237.2016
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