The Δ133p53 Isoform Reduces Wtp53-induced Stimulation of DNA Pol γ Activity in the Presence and Absence of D4T

The mitochondrial toxicity of nucleoside reverse transcriptase inhibitors (NRTIs) is due to the inhibition of mitochondrial DNA (mtDNA) polymerase γ (pol γ). Previous studies have shown that wild type p53 (wtp53) can interact with pol γ and mtDNA to enhance mitochondrial DNA base excision repair (mt...

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Bibliographic Details
Published in:Aging Dis
Main Authors: Liu, Kai, Zang, Yunjin, Guo, Xianghua, Wei, Feili, Yin, Jiming, Pang, Lijun, Chen, Dexi
Format: Artigo
Language:Inglês
Published: JKL International LLC 2017
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5362181/
https://ncbi.nlm.nih.gov/pubmed/28400988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14336/AD.2016.0910
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