APT2 inhibition restores Scribble localization and S-palmitoylation in Snail-transformed cells

The multi-domain scaffolding protein Scribble (Scrib) organizes key signaling complexes to specify basolateral cell polarity and suppress aberrant growth. In many human cancers, genetically normal Scrib mislocalizes from cell–cell junctions to the cytosol, correlating with enhanced growth signaling...

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Bibliografiske detaljer
Udgivet i:Cell Chem Biol
Main Authors: Hernandez, Jeannie L., Davda, Dahvid, Kit, Melanie Cheung See, Majmudar, Jaimeen D., Won, Sang Joon, Gang, Margery, Pasupuleti, Sirisha C., Choi, Alexandria I., Bartkowiak, Callie M., Martin, Brent R.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5362123/
https://ncbi.nlm.nih.gov/pubmed/28065656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2016.12.007
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