Molecular mechanism for isoform-selective inhibition of acyl protein thioesterases 1 and 2 (APT1 and APT2)

Post-translational S-palmitoylation directs the trafficking and membrane localization of hundreds of cellular proteins, often involving a coordinated palmitoylation cycle that requires both protein acyl transferases (PATs) and acyl protein thioesterases (APTs) to actively re-distribute S-palmitoylat...

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Udgivet i:ACS Chem Biol
Main Authors: Won, Sang Joon, Davda, Dahvid, Labby, Kristin J., Hwang, Sin Ye, Pricer, Rachel, Majmudar, Jaimeen D., Armacost, Kira A., Rodriguez, Laura A., Rodriguez, Christina L., Chong, Fei San, Torossian, Kristopher A., Palakurthi, Jasmine, Hur, Edward S., Meagher, Jennifer L., Brooks, Charles L., Stuckey, Jeanne A., Martin, Brent R.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5359770/
https://ncbi.nlm.nih.gov/pubmed/27748579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.6b00720
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