APT2 inhibition restores Scribble localization and S-palmitoylation in Snail-transformed cells

The multi-domain scaffolding protein Scribble (Scrib) organizes key signaling complexes to specify basolateral cell polarity and suppress aberrant growth. In many human cancers, genetically normal Scrib mislocalizes from cell–cell junctions to the cytosol, correlating with enhanced growth signaling...

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Détails bibliographiques
Publié dans:Cell Chem Biol
Auteurs principaux: Hernandez, Jeannie L., Davda, Dahvid, Kit, Melanie Cheung See, Majmudar, Jaimeen D., Won, Sang Joon, Gang, Margery, Pasupuleti, Sirisha C., Choi, Alexandria I., Bartkowiak, Callie M., Martin, Brent R.
Format: Artigo
Langue:Inglês
Publié: 2017
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5362123/
https://ncbi.nlm.nih.gov/pubmed/28065656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2016.12.007
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