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APT2 inhibition restores Scribble localization and S-palmitoylation in Snail-transformed cells
The multi-domain scaffolding protein Scribble (Scrib) organizes key signaling complexes to specify basolateral cell polarity and suppress aberrant growth. In many human cancers, genetically normal Scrib mislocalizes from cell–cell junctions to the cytosol, correlating with enhanced growth signaling...
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| Publicado no: | Cell Chem Biol |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5362123/ https://ncbi.nlm.nih.gov/pubmed/28065656 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2016.12.007 |
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