Hypoxia induces H19 expression through direct and indirect Hif-1α activity, promoting oncogenic effects in glioblastoma

H19 expression is elevated in many human tumors including glioblastomas, suggesting an oncogenic role for the long noncoding RNA; yet the upregulation of H19 in glioblastomas remains unclear. Here we report that hypoxia significantly stimulated H19 expression in glioblastoma cell lines, which was re...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Wu, Weining, Hu, Qi, Nie, Er, Yu, Tianfu, Wu, Youzhi, Zhi, Tongle, Jiang, Kuan, Shen, Feng, Wang, Yingyi, Zhang, Junxia, You, Yongping
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5361208/
https://ncbi.nlm.nih.gov/pubmed/28327666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep45029
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