Structure-guided development of a high-affinity human Programmed Cell Death-1: Implications for tumor immunotherapy

Programmed Cell Death-1 (PD-1) is an inhibitory immune receptor, which plays critical roles in T cell co-inhibition and exhaustion upon binding to its ligands PD-L1 and PD-L2. We report the crystal structure of the human PD-1 ectodomain and the mapping of the PD-1 binding interface. Mutagenesis stud...

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Sparad:
Bibliografiska uppgifter
I publikationen:EBioMedicine
Huvudupphovsmän: Lázár-Molnár, Eszter, Scandiuzzi, Lisa, Basu, Indranil, Quinn, Thomas, Sylvestre, Eliezer, Palmieri, Edith, Ramagopal, Udupi A., Nathenson, Stanley G., Guha, Chandan, Almo, Steven C.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Elsevier 2017
Ämnen:
Research Paper
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5360572/
https://ncbi.nlm.nih.gov/pubmed/28233730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2017.02.004
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