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Reducing Timp3 or Vitronectin Ameliorates Disease Manifestations in CADASIL Mice
OBJECTIVE: CADASIL is a genetic paradigm of cerebral small vessel disease caused by NOTCH3 mutations that stereotypically lead to the extracellular deposition of NOTCH3 ectodomain (Notch3(ECD)) on the vessels. TIMP3 and vitronectin are 2 extracellular matrix proteins that abnormally accumulate in No...
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| Pubblicato in: | Ann Neurol |
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| Autori principali: | , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5359978/ https://ncbi.nlm.nih.gov/pubmed/26648042 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ana.24573 |
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