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Increased Notch3 Activity Mediates pathological Changes in Structure of Cerebral arteries

CADASIL, the most frequent genetic cause of stroke and vascular dementia, is caused by highly stereotyped mutations in the NOTCH3 receptor, which is predominantly expressed in vascular smooth muscle. The well-established TgNotch3(R169C) mouse model develops characteristic features of the human disea...

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Detalhes bibliográficos
Publicado no:Hypertension
Main Authors: Baron-Menguy, Celine, Domenga-Denier, Valérie, Ghezali, Lamia, Faraci, Frank, Joutel, Anne
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5145742/
https://ncbi.nlm.nih.gov/pubmed/27821617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/HYPERTENSIONAHA.116.08015
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