Mechanistic insights into a TIMP3-sensitive pathway constitutively engaged in the regulation of cerebral hemodynamics

Cerebral small vessel disease (SVD) is a leading cause of stroke and dementia. CADASIL, an inherited SVD, alters cerebral artery function, compromising blood flow to the working brain. TIMP3 (tissue inhibitor of metalloproteinase 3) accumulation in the vascular extracellular matrix in CADASIL is a k...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:eLife
Main Authors: Capone, Carmen, Dabertrand, Fabrice, Baron-Menguy, Celine, Chalaris, Athena, Ghezali, Lamia, Domenga-Denier, Valérie, Schmidt, Stefanie, Huneau, Clément, Rose-John, Stefan, Nelson, Mark T, Joutel, Anne
Format: Artigo
Jezik:Inglês
Izdano: eLife Sciences Publications, Ltd 2016
Teme:
Human Biology and Medicine
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4993587/
https://ncbi.nlm.nih.gov/pubmed/27476853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.17536
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