Mechanistic insights into a TIMP3-sensitive pathway constitutively engaged in the regulation of cerebral hemodynamics

Cerebral small vessel disease (SVD) is a leading cause of stroke and dementia. CADASIL, an inherited SVD, alters cerebral artery function, compromising blood flow to the working brain. TIMP3 (tissue inhibitor of metalloproteinase 3) accumulation in the vascular extracellular matrix in CADASIL is a k...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Capone, Carmen, Dabertrand, Fabrice, Baron-Menguy, Celine, Chalaris, Athena, Ghezali, Lamia, Domenga-Denier, Valérie, Schmidt, Stefanie, Huneau, Clément, Rose-John, Stefan, Nelson, Mark T, Joutel, Anne
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2016
Assuntos:
Human Biology and Medicine
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4993587/
https://ncbi.nlm.nih.gov/pubmed/27476853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.17536
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