Increased virulence of neuraminidase inhibitor-resistant pandemic H1N1 virus in mice: Potential emergence of drug-resistant and virulent variants

Pandemic H1N1 2009 (A[H1N1]pdm09) variants associated with oseltamivir resistance have emerged with a histidine-to-tyrosine substitution in the neuraminidase(NA) at position 274 (H274Y). To determine whether the H274Y variant has increased virulence potential, A(H1N1)pdm09 virus, with or without the...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Virulence
Hauptverfasser: Song, Min-Suk, Hee Baek, Yun, Kim, Eun-Ha, Park, Su-Jin, Kim, Semi, Lim, Gyo-Jin, Kwon, Hyeok-il, Pascua, Philippe Noriel Q, Decano, Arun G, Lee, Byeong-Jae, Kim, Young-Il, Webby, Richard J, Choi, Young-Ki
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis 2013
Schlagworte:
Brief Report
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5359727/
https://ncbi.nlm.nih.gov/pubmed/23924955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/viru.25952
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