A Novel Neuraminidase-Dependent Hemagglutinin Cleavage Mechanism Enables the Systemic Spread of an H7N6 Avian Influenza Virus

In this study, we demonstrate a novel mechanism for hemagglutinin (HA) activation in a naturally occurring H7N6 avian influenza A virus strain, A/mallard duck/Korea/6L/2007 (A/Mdk/6L/07). This novel mechanism allows for systemic infection of chickens, ducks, and mice, and A/Mdk/6L/07 can replicate i...

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Detalhes bibliográficos
Publicado no:mBio
Main Authors: Kwon, Hyeok-il, Kim, Young-Il, Park, Su-Jin, Kim, Eun-Ha, Kim, Semi, Si, Young-Jae, Song, Min-Suk, Pascua, Philippe Noriel Q., Govorkova, Elena A., Webster, Robert G., Webby, Richard J., Choi, Young Ki
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6831776/
https://ncbi.nlm.nih.gov/pubmed/31690675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.02369-19
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