Virulence and Genetic Compatibility of Polymerase Reassortant Viruses Derived from the Pandemic (H1N1) 2009 Influenza Virus and Circulating Influenza A Viruses

Gene mutations and reassortment are key mechanisms by which influenza A virus acquires virulence factors. To evaluate the role of the viral polymerase replication machinery in producing virulent pandemic (H1N1) 2009 influenza viruses, we generated various polymerase point mutants (PB2, 627K/701N; PB...

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Main Authors: Song, Min-Suk, Pascua, Philippe Noriel Q., Lee, Jun Han, Baek, Yun Hee, Park, Kuk Jin, Kwon, Hyeok-il, Park, Su-Jin, Kim, Chul-Joong, Kim, Hyunggee, Webby, Richard J., Webster, Robert G., Choi, Young Ki
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Microbiology 2011
נושאים:
Genetic Diversity and Evolution
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3126523/
https://ncbi.nlm.nih.gov/pubmed/21507962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02125-10
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