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Checkpoint-Independent Regulation of Origin Firing by Mrc1 through Interaction with Hsk1 Kinase
Mrc1 is a conserved checkpoint mediator protein that transduces the replication stress signal to the downstream effector kinase. The loss of mrc1 checkpoint activity results in the aberrant activation of late/dormant origins in the presence of hydroxyurea. Mrc1 was also suggested to regulate orders...
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| Pubblicato in: | Mol Cell Biol |
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| Autori principali: | , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Microbiology
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5359423/ https://ncbi.nlm.nih.gov/pubmed/28069740 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00355-16 |
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