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Checkpoint-Independent Regulation of Origin Firing by Mrc1 through Interaction with Hsk1 Kinase

Mrc1 is a conserved checkpoint mediator protein that transduces the replication stress signal to the downstream effector kinase. The loss of mrc1 checkpoint activity results in the aberrant activation of late/dormant origins in the presence of hydroxyurea. Mrc1 was also suggested to regulate orders...

詳細記述

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書誌詳細
出版年:Mol Cell Biol
主要な著者: Matsumoto, Seiji, Kanoh, Yutaka, Shimmoto, Michie, Hayano, Motoshi, Ueda, Kyosuke, Fukatsu, Rino, Kakusho, Naoko, Masai, Hisao
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Microbiology 2017
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5359423/
https://ncbi.nlm.nih.gov/pubmed/28069740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00355-16
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