D120 and K152 within the PH Domain of T Cell Adapter SKAP55 Regulate Plasma Membrane Targeting of SKAP55 and LFA-1 Affinity Modulation in Human T Lymphocytes

The β2-integrin lymphocyte function-associated antigen 1 (LFA-1) is needed for the T cell receptor (TCR)-induced activation of LFA-1 to promote T cell adhesion and interaction with antigen-presenting cells (APCs). LFA-1-mediated cell-cell interactions are critical for proper T cell differentiation a...

Full description

Saved in:
Bibliographic Details
Published in:Mol Cell Biol
Main Authors: Witte, Amelie, Meineke, Bernhard, Sticht, Jana, Philipsen, Lars, Kuropka, Benno, Müller, Andreas J., Freund, Christian, Schraven, Burkhart, Kliche, Stefanie
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2017
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5359422/
https://ncbi.nlm.nih.gov/pubmed/28052935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00509-16
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items