Chromosome conformation elucidates regulatory relationships in developing human brain

Three-dimensional physical interactions within chromosomes dynamically regulate gene expression in a tissue-specific manner(1–3). However, the 3D organization of chromosomes during human brain development and its role in regulating gene networks dysregulated in neurodevelopmental disorders, such as...

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Udgivet i:Nature
Main Authors: Won, Hyejung, de la Torre-Ubieta, Luis, Stein, Jason L., Parikshak, Neelroop N., Huang, Jerry, Opland, Carli K., Gandal, Michael, Sutton, Gavin J., Hormozdiari, Farhad, Lu, Daning, Lee, Changhoon, Eskin, Eleazar, Voineagu, Irina, Ernst, Jason, Geschwind, Daniel H.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5358922/
https://ncbi.nlm.nih.gov/pubmed/27760116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature19847
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