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Quenched hydrogen-deuterium exchange NMR of a disease-relevant Aβ(1-42) amyloid polymorph

Alzheimer’s disease is associated with the aggregation into amyloid fibrils of Aβ(1–42) and Aβ(1–40) peptides. Interestingly, these fibrils often do not obtain one single structure but rather show different morphologies, so-called polymorphs. Here, we compare quenched hydrogen-deuterium (H/D) exchan...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Wälti, Marielle Aulikki, Orts, Julien, Riek, Roland
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5358797/
https://ncbi.nlm.nih.gov/pubmed/28319116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0172862
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