Oncogenic Kras drives invasion and maintains metastases in colorectal cancer

Human colorectal cancer (CRC) is a major cause of cancer mortality and frequently harbors activating mutations in the KRAS gene. To understand the role of oncogenic KRAS in CRC, we engineered a mouse model of metastatic CRC that harbors an inducible oncogenic Kras allele (Kras(mut)) and conditional...

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Bibliografische gegevens
Gepubliceerd in:Genes Dev
Hoofdauteurs: Boutin, Adam T., Liao, Wen-Ting, Wang, Melody, Hwang, Soyoon Sarah, Karpinets, Tatiana V., Cheung, Hannah, Chu, Gerald C., Jiang, Shan, Hu, Jian, Chang, Kyle, Vilar, Eduardo, Song, Xingzhi, Zhang, Jianhua, Kopetz, Scott, Futreal, Andrew, Wang, Y. Alan, Kwong, Lawrence N., DePinho, Ronald A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Cold Spring Harbor Laboratory Press 2017
Onderwerpen:
Research Paper
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5358757/
https://ncbi.nlm.nih.gov/pubmed/28289141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.293449.116
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