Yap1 activation enables bypass of oncogenic Kras addiction in pancreatic cancer

Activating mutations in KRAS are among the most frequent events in diverse human carcinomas and are particularly prominent in human pancreatic ductal adenocarcinoma (PDAC). An inducible Kras(G12D)-driven mouse model of PDAC has established a critical role for sustained Kras(G12D) expression in tumor...

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Detalhes bibliográficos
Main Authors: Kapoor, Avnish, Yao, Wantong, Ying, Haoqiang, Hua, Sujun, Liewen, Alison, Wang, Qiuyun, Zhong, Yi, Wu, Chang-Jiun, Sadanandam, Anguraj, Hu, Baoli, Chang, Qing, Chu, Gerald C., Al-Khalil, Ramsey, Jiang, Shan, Xia, Hongai, Fletcher-Sananikone, Eliot, Lim, Carol, Horwitz, Gillian I., Viale, Andrea, Pettazzoni, Piergiorgio, Sanchez, Nora, Wang, Huamin, Protopopov, Alexei, Zhang, Jianhua, Heffernan, Timothy, Johnson, Randy L., Chin, Lynda, Wang, Y. Alan, Draetta, Giulio, DePinho, Ronald A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4109295/
https://ncbi.nlm.nih.gov/pubmed/24954535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2014.06.003
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