OP08. Mutations in the IDH gene (R132H) are not sufficient for experimental gliomagenesis

INTRODUCTION: Mutations in isocitrate dehydrogenase (IDH), primarily IDH1R132H, are associated with favourable prognosis and are defining features of oligodendrogliomas and astrocytomas. They produce the oncometabolite 2-hydroxyglutarate which interferes with the TET family of 5’-methylcytosine hydr...

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Published in:Neuro Oncol
Main Authors: Ningning, Dr Li, Sidlauskas, Mr Kastytis, Zhang, Ms Ying, Ferreira, Ms Andreia, Lau, Ms Joanne, Pusch, Dr Stefan, Von Deimling, Prof Andreas, Brandner, Prof Sebastian
Format: Artigo
Language:Inglês
Published: Oxford University Press 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5358561/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/now292.007
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